湖南雅湘DNA亲子鉴定咨询中心 网站地图     鉴定新闻
湖南雅湘DNA亲子鉴定咨询咨询中心首页湖南DNA亲子鉴定咨询中心服务项目亲子鉴定咨询DNA鉴定相关知识司法亲子鉴定咨询个人亲子鉴定咨询申请流程亲子鉴定咨询DNA鉴定的采样方式湖南雅湘DNA亲子鉴定咨询中心收费标准湖南雅湘DNA亲子鉴定咨询中心联络方式衡阳亲子鉴定咨询中心衡阳DNA鉴定机构
衡阳亲子鉴定中心衡阳DNA鉴定机构-湖南雅湘DNA亲子鉴定咨询中心
亲子鉴定常见问题
何为亲子鉴定
司法亲子鉴定所需流程
DNA亲子鉴定需要几个人做
什么是个人亲子鉴定
为什么要选择个人亲子鉴定
亲子鉴定与DNA鉴定的区别
DNA亲子鉴定原理
亲子鉴定的常见用途
严格按照AABB和ISO17025的要求鉴定

DNA亲子鉴定新闻

TCGA数据挖掘文章iF4.99:TFAP2B与子宫内膜癌预后研究

发表日期:2018-3-29 来源:湖南雅湘亲子鉴定中心

妇科肿瘤杂志 https://www.sciencedirect.com/science/article/pii/S0090825818302373 

Decreased expression of TFAP2B in endometrial cancer predicts poor prognosis: A study based on TCGA data


Highlights

A reduced expression of TFAP2B in endometrial cancer was associated with advanced clinical pathologic characteristics.

TFAP2B is an independent predictor for survival in endometrial cancer.

The p53/hypoxia, androgen response and notch signaling pathway may be the key pathway regulated by TFAP2B in EC.


Abstract

Background

Transcription factor activator protein-2β (TFAP-2β) was previously reported to constituted promoter activity in endometrial carcinoma (EC). We evaluated the role of TFAP2B in ECs using publicly available data from The Cancer Genome Atlas (TCGA).

Methods

The relationship between clinical pathologic features and TFAP2B were analyzed with the Wilcoxon signed-rank test and logistic regression. Clinicopathologic characteristics associated with overall survival in TCGA patients using Cox regression and the Kaplan-Meier method. Gene Set Enrichment Analysis (GSEA) was performed using TCGA data set.

Results

Reduced TFAP2B expression in EC was significantly associated with high grade (OR = 2.2 for well, moderate vs. poor), stage (OR = 2.5 for I vs. IV), histology (OR = 1.8 for serous vs. endometrioid), distant metastasis (OR = 2.4 for positive vs. negative) (all p-values < 0.05). Kaplan-Meier survival analysis showed that EC with TFAP2B-low had a worse prognosis than that with TFAP2B-high (p = 0.013). The univariate analysis revealed that TFAP2B-low correlated significantly with a poor overall survival (OS) (HR: 2.35; 95% confidence interval [CI]: 1.17–4.73; p = 0.016). The multivariate analysis revealed that TFAP2B remained independently associated with overall survival, with a HR of 4.42 (CI: 1.25–12.64; p = 0.021). GSEA show that p53/hypoxia pathway, androgen response, notch signaling, fatty acid metabolism, glycolysis and estrogen response late are differentially enriched in TFAP2B high expression phenotype.

Conclusions

TFAP2B expression may be a potential prognostic molecular marker of poor survival in endometrial cancer, Moreover, the p53/hypoxia, androgen response and notch signaling pathway may be the key pathway regulated by TFAP2B in EC.

Keywords

  • TFAP2B; 
  • Endometrial cancer; 
  • Prognosis; 
  • TCGA; 
  • GSEA


相关新闻:
返回  收藏此页 打印本页  关闭
DNA亲子鉴定 人民币1250元/人 ——鉴定过程绝对保密 专家热线:0734-2576075 15367984271
鉴定新闻   友情链接   网站地图   关于我们   企业文化   中心寄语   衡阳亲子鉴定   深圳亲子鉴定   福建亲子鉴定   江西亲子鉴定   湖南亲子鉴定   移民亲子鉴定

联系地址:湖南省长沙市岳麓区桐梓坡路172号湘腾城市广场2605室       版权所有©2005-2009 湖南雅湘DNA亲子鉴定咨询中心